CELL INJURY
Mechanism of injury:
4 important events are:
- membrane damage
- mitochondrion damage and depletion of ATP
- Influx of calcium
- Accumulation of oxygen-derived free radicals
At beginning of injury, before energy exhausted, the lysosome will be active, engulf exogenous particles (heterophagy and endogenous particles, such as degrading protein and senescent organelles—-autophagy, we have known that lipofuscin is a residum of autophagic vacuole. Note all work be done inside the lysosome. The membrane keep other normal components in cell far from hydrolyses in the lysosome.
When the injury is severe and energy exhaust the permeability of lysosome membrane increase, various hydrolases will release out to degrade the components of protein and lipids in cytoplasm or on cell membrane. At last cell is broken.
https://www.hanxinclinic.com/index.php/2019/12/06/cell-injury-2/
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