Lung Carcinoma

  • Origin: mostly bronchial epithelium
  • the most frequently diagnosed cancer in the world
  • the most common cause of cancer mortality worldwide
  • Ages: 40-70 y, males > females

Epidemiology:

ETIOLOGIES:

  • Tobacco Smoking
  •  Industrial hazards and air pollution
  •  Molecular genetics

Histogenesis:

Bronchial columnar epithelium→metaplasia→dysplasia→Squamous cell carcinoma
Bronchial columnar epithelium and glandular epithelium→Adenocarcinoma
Clara cell
→ bronchioloalveolar carcinoma
Type II pneumocytes
Neuroendocrine argentaffin (Kulchitsky) cells → Small cell lung carcinoma
neuroendocrine cells (unclear)                         → Large cell lung carcinoma

Morphology:

  • Grossly   

  1.   Central (bronchogenic) carcinoma
  2.   Peripheral carcinoma
  3.   Diffuse type (rare)
https://www.hanxinclinic.com/index.php/2019/09/12/lung-carcinoma/

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